The paper focused on the possible links among pollution, pollution management efficiency including waste management and the propensity of a variety of emerging diseases in our society by answering the question: “How pollution can affect human health?” Environmental pollution is a reality and our planet ecosystem possibilities to face the challenges due to the constant exceeding its resilience are becoming smaller and smaller. The evolution of the climate change indicators like global temperature, global CO2 emissions, oceans acidification and species extinction point out that in a not very long period of time, the planet will not be able to sustain any more the present society’s life style set by the current economic development. Therefore, many warning signals have been issued to change the present behavior in order to reduce significant damages done to the environment and on human health with serious implications on the dysregulation of our immunity and the onset of a plethora of diseases. In this respect, the present paper reviewed relevant aspects linked to the environmental pollution issues that become part of scientific and public debates presented in specialty literature in recent years emphasizing why the implementation of “One Health” concept is necessary.